Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.58 |
| ▸ | CA9 | Q16790 | 9/20 | 0.58 |
| ▸ | CA12 | O43570 | 7/20 | 0.58 |
| ▸ | CA1 | P00915 | 10/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.49 |
| ▸ | TTK | P33981 | 3/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032548 | 0.88 | CA2 (0.73) | CA2CA9CA12CA1CA4 | |
| SCHEMBL1926937 | 0.84 | CA2 (0.67) | CA2CA9CA12CA1CA4 | |
| SCHEMBL6296397 | 0.82 | CA2 (0.53) | CA2CA9CA12CA1CA4 | |
| SCHEMBL145847 | 0.81 | NR1H2 (0.45) | CA2CA9CA12 | |
| SCHEMBL7113274 | 0.79 | CA2 (0.68) | CA2CA9CA12CA1CA4 | |
| SCHEMBL3133153 | 0.79 | ALDH1A1 (0.54) | — | |
| SCHEMBL27491694 | 0.78 | CA2 (0.73) | CA2CA9CA12CA1CA4 | |
| Trimethylammonium SCHEMBL27979850 | 0.78 | CA2 (0.58) | CA2CA9CA12CA1CA4 | |
| SCHEMBL27990769 | 0.78 | MAOA (0.68) | CA2CA9CA12CA1TTK | |
| SCHEMBL6848937 | 0.78 | CA2 (0.68) | CA2CA9CA12CA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566373-B2 | For therapy of osteoporosis, periodontitis, and arthritis | SMITHKLINE BEECHAM CORPORATION | 2003-05-20 | — | — | US | disclosed |