Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235534 | 0.86 | MAPT (0.43) | MEN1ALDH1A1CYP3A4CYP2D6MAPT | |
| SCHEMBL7226596 | 0.84 | MEN1 (0.54) | MEN1ALDH1A1CYP3A4CYP2D6MAPT | |
| SCHEMBL7227719 | 0.77 | MAPT (0.46) | MEN1ALDH1A1CYP3A4CYP2D6MAPT | |
| SCHEMBL7225773 | 0.73 | MAPT (0.50) | MEN1ALDH1A1CYP3A4CYP2D6MAPT | |
| SCHEMBL7226930 | 0.72 | CA1 (0.39) | MEN1ALDH1A1CYP3A4CYP2D6MAPT | |
| SCHEMBL5048632 | 0.69 | GRIA2 (0.67) | MEN1ALDH1A1CYP3A4CYP2D6MAPT | |
| SCHEMBL8345582 | 0.64 | MEN1 (0.47) | MEN1ALDH1A1CYP3A4CYP2D6MAPT | |
| SCHEMBL8345585 | 0.64 | MEN1 (0.47) | MEN1ALDH1A1CYP3A4CYP2D6MAPT | |
| SCHEMBL10887479 | 0.60 | GRIA2 (0.76) | MEN1ALDH1A1CYP3A4CYP2D6MAPT | |
| Gyki-52466 SCHEMBL29357520 | 0.60 | GRIA2 (1.00) | MEN1ALDH1A1CYP3A4CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6600036-B2 | Treating diseases of the central nervous system. | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-07-29 | — | — | US | disclosed |
| US-20020052364-A1 | Condensed 2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2002-05-02 | — | — | US | disclosed |
| EP-0888356-B1 | CONDENSED 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AG (DE) | 2002-03-20 | — | — | EP | disclosed |
| US-6323197-B1 | NON-COMPETITIVE INHIBITING OF THE AMPA RECEPTORS, THESE COMPOUNDS CAN BE USED AS MEDICAMENTS FOR TREATMENT OF THE CENTRAL NERVOUS SYSTEM | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-11-27 | — | — | US | disclosed |
| EP-0888356-A1 | CONDENSED 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028163-A1 | CONDENSED 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052364-A1 | Condensed 2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors | GABRE, GABRA2, GABRB2 | MEN1 4186/4885ALDH1A1 1024/4885CYP3A4 507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.