SCHEMBL7236189

SCHEMBL7236189

CCOC(=O)c1n[c]sc1C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
CYP1A2 P05177 2/20 0.44
GAA P10253 3/20 0.42
TSHR P16473 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
FHIT P49789 1/20 0.40
POLB P06746 1/20 0.40
ILK Q13418 1/20 0.39
KDM4E B2RXH2 4/20 0.39
MAPT P10636 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HPGD P15428 1/20 0.39
LMNA P02545 2/20 0.39
RAB9A P51151 2/20 0.39
TP53 P04637 1/20 0.39
ALOX12 P18054 1/20 0.39
ALOX15 P16050 1/20 0.38
NPC1 O15118 1/20 0.38
CYP2C9 P11712 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9842107 0.84 ALDH1A1 (0.50) ALDH1A1CYP1A2GAATSHRKMT2A
SCHEMBL27855619 0.82 ALDH1A1 (0.41) ALDH1A1CYP1A2GAATSHRMEN1
SCHEMBL27855697 0.82 ALDH1A1 (0.41) ALDH1A1CYP1A2GAATSHRPOLB
SCHEMBL8632808 0.82 ALDH1A1 (0.49) ALDH1A1CYP1A2GAAMEN1KMT2A
SCHEMBL971952 0.74 ALDH1A1 (0.44) ALDH1A1CYP1A2GAATSHRKMT2A
SCHEMBL972466 0.71 SMN1; SMN2 (0.40) ALDH1A1GAAMEN1KMT2APOLB
SCHEMBL2442977 0.71 LMNA (0.49) ALDH1A1CYP1A2GAAMEN1KMT2A
SCHEMBL2438503 0.71 ILK (0.38) ALDH1A1CYP1A2TSHRMEN1KMT2A
SCHEMBL2439651 0.71 MAPT (0.36) ALDH1A1CYP1A2TSHRMEN1KMT2A
SCHEMBL2439320 0.70 POLB (0.49) ALDH1A1CYP1A2GAAKMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102942565-A 3,4-dichloro isothiazole derivatives, their preparation method and application JIANGXI TIANREN ECOLOGY CO LTD 2013-02-27 CN claimed
CN-102942565-B One class 3,4-dichloro Isothizole derivatives and its production and use JIANGXI TIANREN ECOLOGY CO., LTD. (CN) 2016-01-27 CN disclosed
CN-102007116-B Pyridazinone glucokinase activators HOFFMAN-LA ROCHE LTD. (CH) 2014-10-22 CN disclosed
CN-102947311-A 3-oxo-3, 9-dihydro-1H-benzopyrano [2,3-C ] pyrroles as glucokinase activators HOFFMANN LA ROCHE 2013-02-27 CN disclosed
CN-102942565-A 3,4-dichloro isothiazole derivatives, their preparation method and application JIANGXI TIANREN ECOLOGY CO LTD 2013-02-27 CN disclosed
CN-102007116-A Pyridazinone glucokinase activators HOFFMANN LA ROCHE 2011-04-06 CN disclosed
CN-102007118-A Pyrrolidinone glucokinase activators HOFFMANN LA ROCHE 2011-04-06 CN disclosed
US-6583133-B1 Especially against Gram-positive organisms, e.g. methicillin-sensitive (MSSA) and methicillin- resistant (MRSA) staphylococci, enterococci and pneumococci BASILEA PHARMACEUTICA AG (CH) 2003-06-24 US disclosed
EP-1090013-A1 PROPENYL CEPHALOSPORIN DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2001-04-11 EP disclosed
WO-1999067255-A1 PROPENYL CEPHALOSPORIN DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-12-29 WO disclosed
US-5773456-A EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS SANOFI (FR) 1998-06-30 US disclosed
US-5578623-A DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS STERLING WINTHROP INC. (US) 1996-11-26 US disclosed
US-5464852-A Used in treatment of degenerative diseases STERLING WINTHROP INC. (US) 1995-11-07 US disclosed
US-5380737-A Enzyme inhibitors STERLING WINTHROP INC. (US) 1995-01-10 US disclosed
EP-0542371-A1 Saccharin derivative proteolytic enzyme inhibitors STERLING WINTHROP INC. (US) 1993-05-19 EP disclosed