Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 15/20 | 0.65 |
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.49 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7227936 | 0.85 | FFAR4 (0.67) | FFAR1FFAR4MMEL1 | |
| SCHEMBL7725124 | 0.83 | FFAR1 (0.58) | FFAR1FFAR4MMEL1MME | |
| SCHEMBL14340873 | 0.82 | FFAR1 (0.60) | FFAR1FFAR4POLB | |
| SCHEMBL1566761 | 0.82 | FFAR1 (0.73) | FFAR1FFAR4ALDH1A1MAPTPOLB | |
| SCHEMBL3677264 | 0.81 | FFAR1 (0.66) | FFAR1FFAR4MMEL1MME | |
| SCHEMBL8984877 | 0.81 | FFAR1 (0.57) | FFAR1FFAR4 | |
| SCHEMBL7235666 | 0.80 | TPH1 (0.69) | ALDH1A1MAPTHPGD | |
| SCHEMBL274471 | 0.80 | FFAR1 (0.81) | FFAR1FFAR4ALDH1A1POLB | |
| SCHEMBL30792366 | 0.80 | FFAR1 (0.81) | FFAR1FFAR4ALDH1A1POLB | |
| SCHEMBL27637469 | 0.80 | FFAR1 (0.59) | FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645939-B1 | Very late antigen-4 (VLA) integrin antagonists; antiallergens, antiasthmatics, and antiinflammatory agents; multiple sclerosis, autoimmune disease treatment | MERCK & CO., INC. | 2003-11-11 | — | — | US | disclosed |
| WO-2000071572-A1 | SUBSTITUTED BETA-ALANINE DERIVATIVES AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 2000-11-30 | — | — | WO | disclosed |