Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 3/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | DRD4 | P21917 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | SLC6A12 | P48065 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8706525 | 0.93 | CCR3 (0.73) | CCR3SIGMAR1POLBDRD4 | |
| SCHEMBL13580486 | 0.91 | CCR3 (0.67) | CCR3SIGMAR1POLBDRD4MEN1 | |
| SCHEMBL3731091 | 0.89 | DRD4 (0.68) | CCR3SIGMAR1POLBDRD4MEN1 | |
| SCHEMBL6715786 | 0.86 | CCR3 (0.62) | CCR3SIGMAR1POLBDRD4MEN1 | |
| SCHEMBL8706275 | 0.86 | DRD2 (0.65) | CCR3SIGMAR1POLBDRD4 | |
| SCHEMBL8706527 | 0.86 | DRD4 (0.74) | CCR3POLBDRD4SLC6A12 | |
| SCHEMBL8711089 | 0.85 | CCR3 (0.75) | CCR3SIGMAR1POLBDRD4SLC6A12 | |
| SCHEMBL18844432 | 0.84 | CCR3 (1.00) | CCR3MCHR1 | |
| SCHEMBL13841347 | 0.84 | MLNR (0.56) | CCR3SIGMAR1POLBDRD4GAA | |
| SCHEMBL8712704 | 0.84 | DRD2 (0.76) | CCR3SIGMAR1POLBDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617325-B1 | Inhibitors of the microsomal triglyceride-transfer protein | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-09-09 | — | — | US | disclosed |
| WO-1998037064-A1 | BENZAMIDES HAVING DOPAMINE D4 RECEPTOR AFFINITY | HOECHST MARION ROUSSEL, INC. (US) | 1998-08-27 | — | — | WO | disclosed |
| US-5028616-A | Antiarrhythmia Agents | G. D. SEARLE & CO. (US) | 1991-07-02 | — | — | US | disclosed |