Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11062894 | 0.77 | POLB (0.42) | CYP3A4CYP2C9CYP2C19GAAPOLB | |
| SCHEMBL17937995 | 0.70 | POLB (0.46) | CYP3A4CYP2C9CYP2C19GAAPOLB | |
| SCHEMBL9067967 | 0.69 | ALDH1A1 (0.41) | LMNACYP3A4CYP2C9CYP2C19GAA | |
| SCHEMBL9162193 | 0.68 | TSHR (0.43) | FDPSCYP3A4CYP2C9CYP2C19GAA | |
| SCHEMBL8549163 | 0.68 | TSHR (0.43) | FDPSCYP3A4CYP2C9CYP2C19GAA | |
| SCHEMBL27666450 | 0.67 | PPARD (0.43) | FDPSCYP3A4CYP2C9CYP2C19POLB | |
| SCHEMBL27268583 | 0.66 | TSHR (0.42) | FDPSCYP3A4CYP2C9CYP2C19GAA | |
| SCHEMBL9237295 | 0.66 | PPARD (0.46) | FDPSCYP3A4CYP2C9CYP2C19GAA | |
| SCHEMBL9767458 | 0.66 | MMP1 (0.45) | MMP1MMP2MMP3MMP8LMNA | |
| SCHEMBL3405218 | 0.65 | LAP3 (0.44) | CYP3A4CYP2C9CYP2C19POLBPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073671-A1 | Non-steroidal ligands for the estrogen receptor | WILLSON TIMOTHY MARK (US) | 2003-04-17 | — | — | US | disclosed |
| US-20010053774-A1 | Non-steroidal ligands for the estrogen receptor | GLAXO WELLCOME INC.. | 2001-12-20 | — | — | US | disclosed |
| US-6207716-B1 | FOR PROPHYLAXIS AND THERAPY OF OSTEOPOROSIS, ARTHRITIS, BREAST CANCER, CARDIOVASCULAR DISEASE | GLAXO WELLCOME INC. | 2001-03-27 | — | — | US | disclosed |
| US-5877219-A | Non-steroidal ligands for the estrogen receptor | GLAXO WELLCOMEINC. (US) | 1999-03-02 | — | — | US | disclosed |
| WO-1999007668-A1 | NON-STEROIDAL LIGANDS FOR THE ESTROGEN RECEPTOR | GLAXO WELLCOME INC. (US) | 1999-02-18 | — | — | WO | disclosed |
| US-5681835-A | USEFUL FOR TREATING OSTEOPOROSIS | GLAXO WELLCOME INC. (US) | 1997-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010053774-A1 | Non-steroidal ligands for the estrogen receptor | ESRRB, ESR2, ESRRA | MMP1 1141/4885MMP2 1205/4885MMP3 653/4885 |
| US-20030073671-A1 | Non-steroidal ligands for the estrogen receptor | ESRRB, ESR2, ESRRA | MMP1 1141/4885MMP2 1205/4885MMP3 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.