Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7234472 | 0.79 | KMT2A (0.45) | ALDH1A1MAPTLMNATSHRMAPK1 | |
| SCHEMBL7233106 | 0.77 | HSD17B14 (0.46) | ALDH1A1MAPTLMNATSHRKDM4E | |
| SCHEMBL7902879 | 0.73 | KMT2A (0.56) | ALDH1A1MAPTLMNATSHRMAPK1 | |
| SCHEMBL15979681 | 0.72 | KDM4E (0.58) | ALDH1A1MAPTLMNAKDM4ENPC1 | |
| SCHEMBL7809416 | 0.65 | GABBR2 (0.47) | LMNATSHRKMT2ACYP1A2GAA | |
| SCHEMBL11078226 | 0.64 | CES2 (0.46) | ALDH1A1 | |
| SCHEMBL7809414 | 0.63 | TACR1 (0.47) | ALDH1A1MAPTLMNAKDM4ENPC1 | |
| SCHEMBL29005627 | 0.63 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNATSHRMAPK1 | |
| SCHEMBL14073806 | 0.62 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNATSHRMAPK1 | |
| SCHEMBL27750806 | 0.62 | ERCC5 (0.47) | ALDH1A1MAPTLMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6503917-B1 | Post-menopause, atherosclerosis, osteoporosis, and Alzheimer*s disease treatment | WYETH, FIVE GIRALDA FARMS | 2003-01-07 | — | — | US | disclosed |
| US-6384058-B1 | COMPOUNDS AS ESTROGENS FOR TREATMENT OF DEFICIENCY | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-07 | — | — | US | disclosed |
| US-6384057-B1 | COMPOUNDS AS ESTROGENS FOR TREATMENT OF DEFICIENCY | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-07 | — | — | US | disclosed |
| US-6384060-B1 | COMPOUNDS AS ESTROGENS FOR TREATMENT OF DEFICIENCY | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-07 | — | — | US | disclosed |
| WO-1999032447-A2 | 2,4,6-TRISUBSTITUTED PYRIDINES WITH ESTROGENIC ACTIVITY AND METHODS FOR THE SOLID PHASE SYNTHESIS THEREOF | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |