Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10916653 | 0.87 | L3MBTL1 (0.51) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8132532 | 0.87 | ALDH1A1 (0.47) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10582796 | 0.86 | ALDH1A1 (0.41) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8027364 | 0.77 | PPARG (0.36) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7898212 | 0.75 | NPSR1 (0.57) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4804002 | 0.74 | MAPK1 (0.71) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28536179 | 0.74 | ATM (0.40) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2891600 | 0.74 | INPPL1 (0.46) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28542859 | 0.73 | THRB (0.45) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2046228 | 0.73 | L3MBTL1 (0.60) | ALDH1A1NPSR1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6630496-B1 | Antiinflammatory agents inhibit phospholipase 2, affecting both protaglandin and leukotriene production; indoles substituted in 2 position by 2,4-dioxo-thiazol-3-yl methylidene | GENETICS INSTITUTE LLC | 2003-10-07 | — | — | US | disclosed |