Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6547633 | 0.88 | BACE1 (0.42) | HDAC4HDAC1ALDH1A1HDAC3HDAC7 | |
| SCHEMBL6677825 | 0.87 | PRMT1 (0.39) | ALDH1A1CTSKMEN1KMT2ACTSS | |
| SCHEMBL6679014 | 0.87 | HDAC4 (0.41) | HDAC4HDAC1ALDH1A1HDAC3HDAC7 | |
| SCHEMBL6676268 | 0.85 | CA1 (0.39) | HDAC4HDAC1ALDH1A1CTSKBACE1 | |
| SCHEMBL6676654 | 0.83 | CTSK (0.43) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL6676396 | 0.81 | KMT2A (0.40) | ALDH1A1MEN1KMT2ALMNAPOLB | |
| SCHEMBL7243182 | 0.80 | AURKA (0.41) | HDAC4HDAC1ALDH1A1HDAC3HDAC7 | |
| SCHEMBL7247298 | 0.79 | CTSK (0.42) | HDAC4HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL6689701 | 0.78 | RXFP1 (0.42) | HDAC1ALDH1A1HDAC3HDAC2HDAC8 | |
| SCHEMBL6675639 | 0.78 | ALDH1A1 (0.47) | HDAC4HDAC1ALDH1A1HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |