Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 10/20 | 0.48 |
| ▸ | CYP26B1 | Q9NR63 | 6/20 | 0.48 |
| ▸ | RARB | P10826 | 4/20 | 0.47 |
| ▸ | RARG | P13631 | 4/20 | 0.47 |
| ▸ | RARA | P10276 | 3/20 | 0.47 |
| ▸ | RXRA | P19793 | 6/20 | 0.47 |
| ▸ | RXRB | P28702 | 5/20 | 0.47 |
| ▸ | RXRG | P48443 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243713 | 0.84 | RXRA (0.68) | CYP26A1CYP26B1RARBRARGRARA | |
| SCHEMBL10645869 | 0.83 | CYP26A1 (0.47) | CYP26A1CYP26B1RARBRARGRARA | |
| SCHEMBL10580178 | 0.78 | CYP26A1 (0.47) | CYP26A1CYP26B1RARBRARGRARA | |
| SCHEMBL7799795 | 0.76 | RARB (0.56) | CYP26A1CYP26B1RARBRARGRARA | |
| SCHEMBL12646783 | 0.75 | RARG (0.55) | CYP26A1CYP26B1RARBRARGRARA | |
| SCHEMBL12517137 | 0.75 | RARB (0.55) | CYP26A1CYP26B1RARBRARGRARA | |
| SCHEMBL7799775 | 0.75 | RXRA (0.55) | CYP26A1CYP26B1RARBRARGRARA | |
| SCHEMBL28543477 | 0.75 | PLAU (0.55) | KDM4ESMN1; SMN2 | |
| SCHEMBL6943030 | 0.74 | RXRA (0.54) | CYP26A1CYP26B1RARBRARGRARA | |
| SCHEMBL2895364 | 0.74 | RARG (0.63) | CYP26A1RARBRARGRARARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682516-A1 | THERAPEUTIC USE OF COMPOUNDS HAVING SELECTIVE AGONIST-LIKE ACTIVITY ON RXR RETINOID RECEPTORS | ALLERGAN, INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994017796-A1 | THERAPEUTIC USE OF COMPOUNDS HAVING SELECTIVE AGONIST-LIKE ACTIVITY ON RXR RETINOID RECEPTORS | ALLERGAN, INC. (US) | 1994-08-18 | — | — | WO | disclosed |