Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARK7 | Q99497 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 9/20 | 0.44 |
| ▸ | CA1 | P00915 | 9/20 | 0.44 |
| ▸ | CA2 | P00918 | 9/20 | 0.44 |
| ▸ | CA9 | Q16790 | 9/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7245333 | 0.80 | ACHE (0.56) | PARK7MAPTTP53CA12CA1 | |
| SCHEMBL7245471 | 0.79 | CA12 (0.39) | PARK7MAPTCA12CA1CA2 | |
| SCHEMBL7243578 | 0.76 | CTRB1 (0.49) | PARK7MAPTTP53ACHECHRM5 | |
| SCHEMBL17165877 | 0.73 | CYP1B1 (0.49) | PARK7MAPTTP53ACHECHRM5 | |
| SCHEMBL7252676 | 0.73 | NAMPT (0.40) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL4908758 | 0.69 | CA1 (0.70) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL4736390 | 0.67 | PARK7 (1.00) | PARK7MAPTTP53CA12CA1 | |
| SCHEMBL7245612 | 0.66 | HDAC1 (0.40) | CA12CA1CA2CA9ACHE | |
| SCHEMBL7248699 | 0.66 | MAPT (0.42) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL30774299 | 0.65 | PARK7 (0.82) | PARK7MAPTTP53ACHECHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586447-B1 | 3,3-disubstituted-oxindole derivatives useful as anticancer agents | PFIZER INC | 2003-07-01 | — | — | US | disclosed |