Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.70 |
| ▸ | CA2 | P00918 | 7/20 | 0.70 |
| ▸ | CA9 | Q16790 | 7/20 | 0.70 |
| ▸ | CA12 | O43570 | 6/20 | 0.70 |
| ▸ | CASP3 | P42574 | 3/20 | 0.63 |
| ▸ | CASP7 | P55210 | 3/20 | 0.63 |
| ▸ | CASP6 | P55212 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | ALDH2 | P05091 | 3/20 | 0.61 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP4 | P49662 | 1/20 | 0.58 |
| ▸ | CASP9 | P55211 | 1/20 | 0.58 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908838 | 0.82 | PARK7 (0.57) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL14876490 | 0.81 | CUL4A (0.48) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL578250 | 0.78 | ACHE (0.74) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL15215078 | 0.78 | ALDH1A1 (0.71) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL4935561 | 0.77 | CASP3 (0.45) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL4935565 | 0.77 | CASP3 (0.45) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL16798714 | 0.76 | ALDH3A1 (1.00) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL5659265 | 0.75 | ALDH1A1 (1.00) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL5114805 | 0.75 | ALDH1A1 (0.71) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL2008621 | 0.75 | ALDH1A1 (0.74) | CA1CA2CA9CA12CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987474-B2 | Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-03-24 | — | — | US | disclosed |
| US-8987474-B2 | Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-03-24 | — | — | US | disclosed |
| US-8987474-B2 | Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-03-24 | — | — | US | disclosed |
| US-20080176309-A1 | 8-hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid (NSC-87877); Src homology-2 domains; Noonan syndrome, cancer | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080176309-A1 | 8-hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid (NSC-87877); Src homology-2 domains; Noonan syndrome, cancer | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-07-24 | — | — | US | disclosed |
| WO-2007117699-A2 | INHIBITION OF SHP2/PTPN11 PROTEIN TYROSINE PHOSPHATASE BY NSC-87877, NSC-117199 AND THEIR ANALOGS | UNIVERSITY OF SOUTH FLORIDA (US) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176309-A1 | 8-hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid (NSC-87877); Src homology-2 domains; Noonan syndrome, cancer | PTPN7, PTPN1, PTPN2 | CA1 4364/4885CA2 3177/4885CA9 4017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.