Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.58 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.52 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27312853 | 0.89 | HPRT1 (0.63) | ALDH1A1HSD17B10HIF1ACYP1B1TRPM4 | |
| SCHEMBL13730705 | 0.87 | ALOX15 (0.44) | ALDH1A1HSD17B10HIF1ATRPM4TSHR | |
| SCHEMBL888299 | 0.83 | ALDH1A1 (0.68) | ALDH1A1HSD17B10HIF1ACYP1B1TRPM4 | |
| SCHEMBL16107521 | 0.83 | ALDH1A1 (0.68) | ALDH1A1HSD17B10HIF1ACYP1B1TRPM4 | |
| SCHEMBL20735853 | 0.81 | ALDH1A1 (0.73) | ALDH1A1HSD17B10HIF1ACYP1B1TRPM4 | |
| SCHEMBL11726972 | 0.79 | TRPM4 (0.68) | ALDH1A1HSD17B10HIF1ACYP1B1TRPM4 | |
| SCHEMBL22142548 | 0.79 | HPRT1 (0.73) | ALDH1A1HSD17B10HIF1ACYP1B1TRPM4 | |
| SCHEMBL13730491 | 0.79 | HPRT1 (0.41) | ALDH1A1HSD17B10TRPM4HPRT1CTDSP1 | |
| SCHEMBL140478 | 0.78 | IDO1 (0.50) | ALDH1A1HSD17B10HIF1ATRPM4TSHR | |
| SCHEMBL8006577 | 0.78 | IDO1 (0.50) | ALDH1A1HSD17B10HIF1ATRPM4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512848-B1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2020-11-18 | — | — | EP | disclosed |
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2019-07-11 | — | — | US | disclosed |
| US-6528517-B1 | Solid phase synthesis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-03-04 | — | — | US | disclosed |
| WO-1999040093-A2 | SYNTHESIS OF QUINOBENZOXAZINE ANALOGUES WITH TOPOISOMERASE II AND QUADRUPLEX INTERACTIONS FOR USE AS ANTINEOPLASTIC AGENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1999-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | CYCS, CYP3A4, CYP2E1 | ALDH1A1 506/4885HSD17B10 2679/4885HIF1A 4503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.