Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | PTPRA | P18433 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL4884024 | 0.87 | SLC7A5 (0.44) | SLC7A5KDM4EPKMPOLBSLC1A3 | |
| Valine SCHEMBL1842424 | 0.82 | TDP1 (0.52) | SLC7A5KDM4EPOLBSLC1A3SLC1A2 | |
| Valine SCHEMBL15208663 | 0.82 | ALDH1A1 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1ALDH1A1 | |
| SCHEMBL29650217 | 0.78 | KDM4E (0.55) | KDM4EPKMPOLBMEN1THRB | |
| SCHEMBL23025 | 0.78 | KDM4E (0.55) | KDM4EPKMPOLBMEN1THRB | |
| Valine SCHEMBL3646564 | 0.77 | NOS3 (0.53) | SLC7A5KDM4EPOLBSLC1A3SLC1A2 | |
| Valine SCHEMBL9359776 | 0.77 | SLC7A5 (0.50) | SLC7A5KDM4EPOLBKMT2ASLC1A3 | |
| Valine SCHEMBL4899677 | 0.76 | SLC7A5 (0.48) | SLC7A5KDM4EPOLBKMT2ASLC1A3 | |
| Valine SCHEMBL20476530 | 0.76 | SLC7A5 (0.48) | SLC7A5KDM4EPOLBSLC1A3SLC1A2 | |
| Hydrochloric Acid SCHEMBL17129 | 0.76 | KDM4E (0.53) | KDM4EPKMPOLBMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598154-B2 | Pyridyl-amine fused azadecalin modulators | CORCEPT THERAPEUTICS, INC. (US) | 2013-12-03 | — | — | US | disclosed |
| EP-2609097-A1 | PYRIDYL-AMINE FUSED AZADECALIN MODULATORS | Corcept Therapeutics, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-20120220565-A1 | PYRIDYL-AMINE FUSED AZADECALIN MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2012-08-30 | — | — | US | disclosed |
| WO-2012027702-A1 | PYRIDYL-AMINE FUSED AZADECALIN MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220565-A1 | PYRIDYL-AMINE FUSED AZADECALIN MODULATORS | NR3C1, NR3C2, NR5A2 | SLC7A5 3702/4885KDM4E 574/4885PKM 3555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.