Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 12/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | NEK4 | P51957 | 1/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7245225 | 0.89 | F2 (0.59) | F2ITKHDAC1 | |
| SCHEMBL7246239 | 0.88 | ITK (0.46) | F2ITKAURKAMAP4K4CHEK2 | |
| SCHEMBL6775078 | 0.83 | ITK (0.43) | F2ITKAURKAMAP4K4CHEK2 | |
| SCHEMBL7245070 | 0.81 | F2 (0.53) | F2HDAC1HDAC8 | |
| SCHEMBL7244643 | 0.80 | F2 (0.50) | F2HDAC1HDAC8 | |
| SCHEMBL7252107 | 0.78 | F2 (0.49) | F2HDAC1HDAC8 | |
| SCHEMBL7247840 | 0.78 | NSD2 (0.52) | F2ITKHDAC1AURKAMAP4K4 | |
| SCHEMBL7243952 | 0.77 | F2 (0.59) | F2ITK | |
| SCHEMBL7245210 | 0.77 | F2 (0.51) | F2ITKHDAC1HDAC8 | |
| SCHEMBL7245646 | 0.77 | F2 (0.63) | F2ITKHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6512000-B1 | Aminocarbonyl- substituted benzimidazole derivatives for the treatment of diseases in which inhibition of tryptase is of therapeutic such as for treating an inflammatory or allergic disease | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-01-28 | — | — | US | disclosed |