Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7249235 | 0.89 | ALDH1A1 (0.53) | ALDH1A1MAPK1CA12CA1CA7 | |
| SCHEMBL7871728 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MAPK1CA12CA1CA7 | |
| SCHEMBL7170109 | 0.80 | ALDH1A1 (0.56) | ALDH1A1MAPK1CA12CA1CA7 | |
| SCHEMBL7871684 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPK1CA12CA1CA7 | |
| SCHEMBL7871686 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPK1CA12CA1CA7 | |
| SCHEMBL7247052 | 0.76 | ALDH1A1 (0.44) | ALDH1A1MAPK1CA12CA1CA7 | |
| SCHEMBL7150009 | 0.75 | ALDH1A1 (0.60) | ALDH1A1MAPK1NPSR1HTTKMT2A | |
| SCHEMBL7152017 | 0.71 | ALDH1A1 (0.60) | ALDH1A1MAPK1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL8467499 | 0.69 | ALDH1A1 (0.63) | ALDH1A1MAPK1CA12CA1CA7 | |
| SCHEMBL6652226 | 0.69 | ALDH1A1 (0.60) | ALDH1A1MAPK1CA12CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030176494-A1 | Novel coumarin and chromene compounds and methods of preparation and use thereof for treating or preventing viral infections | ADVANCED LIFE SCIENCES, INC. | 2003-09-18 | — | — | US | disclosed |
| US-6420571-B2 | Methods for preparing antiviral calanolide compounds | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2002-07-16 | — | — | US | disclosed |
| US-6369241-B1 | MULTISTAGE REACTION OF KETOESTER WITH 1,3,5-TRIHYDROXYBENZENE TO PRODUCE DIHYDROXYOXOCOUMARONE, COUPLING AND CYCLIZATION | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2002-04-09 | — | — | US | disclosed |
| US-20020013480-A1 | Methods for preparing antiviral calanolide compounds | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2002-01-31 | — | — | US | disclosed |
| EP-1173442-A2 | METHODS FOR PREPARING ANTIVIRAL CALANOLIDE COMPOUNDS | Sarawak Medichem Pharmaceuticals Inc. (US) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064903-A2 | METHODS FOR PREPARING ANTIVIRAL CALANOLIDE COMPOUNDS | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 2000-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013480-A1 | Methods for preparing antiviral calanolide compounds | ZC3HAV1, ZC3HAV1L, CYP8B1 | ALDH1A1 911/4885MAPK1 4331/4885CA12 868/4885 |
| US-20030176494-A1 | Novel coumarin and chromene compounds and methods of preparation and use thereof for treating or preventing viral infections | HAVCR2, PROC, CTRC | ALDH1A1 2199/4885MAPK1 1046/4885CA12 1686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.