Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.50 |
| ▸ | NOS1 | P29475 | 3/20 | 0.50 |
| ▸ | NOS2 | P35228 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238763 | 0.87 | TSHR (0.57) | NOS3NOS1NOS2TDP1LTA4H | |
| SCHEMBL7245903 | 0.77 | KDM4E (0.60) | TDP1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL12677020 | 0.76 | NOS3 (0.53) | NOS3NOS1NOS2TDP1MEN1 | |
| SCHEMBL13924773 | 0.75 | TDP1 (0.79) | TDP1MEN1KMT2ALTA4HHTR1A | |
| SCHEMBL1921438 | 0.74 | LTA4H (0.56) | NOS3NOS1NOS2MEN1KMT2A | |
| SCHEMBL12301684 | 0.74 | LTA4H (0.57) | MEN1KMT2ALTA4H | |
| SCHEMBL30975206 | 0.74 | METAP2 (0.50) | TDP1MEN1KMT2ARAB9A | |
| SCHEMBL30975198 | 0.74 | METAP2 (0.50) | TDP1MEN1KMT2ARAB9A | |
| SCHEMBL3450903 | 0.73 | MEN1 (0.58) | MEN1KMT2ALTA4HABCB1HTR1A | |
| SCHEMBL15330618 | 0.73 | ALDH1A1 (0.56) | TDP1MEN1KMT2ALTA4HABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030114449-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2003-06-19 | — | — | US | disclosed |
| EP-1255756-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001044245-A1 | SACCHARIN DERIVATIVES AS ORALLY ACTIVE ELASTASE INHIBITORS | SANOFI-SYNTHELABO (FR) | 2001-06-21 | — | — | WO | disclosed |