Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | APEX1 | P27695 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 7/20 | 0.41 |
| ▸ | CA2 | P00918 | 7/20 | 0.41 |
| ▸ | CA9 | Q16790 | 6/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13982472 | 0.79 | ERN1 (0.44) | PKMTAAR1CA1CA2CA9 | |
| SCHEMBL158153 | 0.78 | TAAR1 (0.56) | ALDH1A1PKMTAAR1CA1CA2 | |
| SCHEMBL29503477 | 0.76 | PTGS2 (0.50) | PKMCA1CA2CA9PTGS2 | |
| SCHEMBL28145710 | 0.76 | CA2 (0.49) | ALDH1A1CA1CA2CA9PTGS2 | |
| SCHEMBL19743928 | 0.76 | PTGS2 (0.50) | PKMCA1CA2CA9PTGS2 | |
| SCHEMBL13012199 | 0.75 | APEX1 (0.50) | KDM4EALDH1A1APEX1CYP2C19CA1 | |
| SCHEMBL30184066 | 0.72 | TAAR1 (0.50) | KDM4EALDH1A1PKMTAAR1TDP1 | |
| SCHEMBL21000886 | 0.72 | TAAR1 (0.50) | KDM4EALDH1A1PKMTAAR1TDP1 | |
| SCHEMBL18713980 | 0.71 | TAAR1 (0.48) | ALDH1A1PKMTAAR1TDP1MAPK1 | |
| SCHEMBL13862076 | 0.71 | TAAR1 (0.48) | KDM4EALDH1A1TAAR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6635635-B2 | 5,5-dioxo-2,3,3a,4-tetrahydro-1 H-pyrrolo(2,1-c)(1,2,4)-benzothiadiazin-7-ol, for example; nervous system disorders; alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) modulators | LES LABORATOIRES SERVIER (FR) | 2003-10-21 | — | — | US | disclosed |
| US-20020037894-A1 | Benzothiadiazine compounds | ADIR ET COMPAGNIE (FR) | 2002-03-28 | — | — | US | disclosed |
| EP-1176148-A1 | Benzothiadiazine derivatives, processes for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2002-01-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037894-A1 | Benzothiadiazine compounds | HCAR1, GLRA1, HCAR2 | KDM4E 3896/4885ALDH1A1 239/4885PKM 2104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.