Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.61 |
| ▸ | CTSS | P25774 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 10/20 | 0.45 |
| ▸ | MMP13 | P45452 | 9/20 | 0.45 |
| ▸ | MMP1 | P03956 | 5/20 | 0.45 |
| ▸ | MMP14 | P50281 | 5/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.45 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 5/20 | 0.43 |
| ▸ | MMP3 | P08254 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | MMP16 | P51512 | 2/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | TARS1 | P26639 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159422 | 0.80 | CTSK (0.56) | CTSKCTSSMMP2MMP13MMP1 | |
| SCHEMBL7163348 | 0.78 | CTSK (0.49) | CTSKCTSSMMP2MMP13MMP1 | |
| SCHEMBL7168737 | 0.78 | CTSK (0.67) | CTSKCTSSMMP2MMP13MMP1 | |
| SCHEMBL7163658 | 0.78 | CTSK (0.64) | CTSKCTSSMMP2MMP13MMP1 | |
| SCHEMBL8247244 | 0.76 | CTSK (1.00) | CTSKCTSSMMP2MMP13MMP1 | |
| SCHEMBL7160493 | 0.76 | CTSK (0.62) | CTSKCTSSMMP2MMP13MMP1 | |
| SCHEMBL7174464 | 0.75 | CTSS (0.58) | CTSKCTSSMMP2MMP13MMP1 | |
| SCHEMBL7165313 | 0.74 | MMP13 (0.60) | CTSKCTSSMMP2MMP13MMP1 | |
| SCHEMBL7248005 | 0.74 | CTSK (0.59) | CTSKCTSSMMP2MMP13MMP1 | |
| SCHEMBL5934588 | 0.73 | CTSK (0.63) | CTSKCTSSMMP13CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586466-B2 | Enzyme inhibitor for use in the treatment of bone, oral, arthritic, paget's and hypercalcemic diseases | SMITHKLINE BEECHAM CORPORATION | 2003-07-01 | — | — | US | disclosed |