SCHEMBL7250205

SCHEMBL7250205

CCNc1c([S+](C)[O-])c(/C=N/O)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GABRB3 P28472 19/20 0.38
GABRA2 P47869 13/20 0.38
GABRB2 P47870 13/20 0.38
GABRP O00591 7/20 0.34
GABRD O14764 7/20 0.34
GABRA1 P14867 7/20 0.34
GABRB1 P18505 7/20 0.34
GABRG2 P18507 7/20 0.34
GABRA5 P31644 7/20 0.34
GABRA3 P34903 7/20 0.34
GABRA4 P48169 7/20 0.34
GABRE P78334 7/20 0.34
GABRA6 Q16445 7/20 0.34
GABRG1 Q8N1C3 7/20 0.34
GABRG3 Q99928 7/20 0.34
GABRQ Q9UN88 7/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7250207 1.00 GABRB3 (0.38) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7028469 0.89 GABRB3 (0.36) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7028465 0.89 GABRB3 (0.36) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7025749 0.83 GABRB3 (0.40) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7025746 0.83 GABRB3 (0.40) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7029932 0.83 GABRP (0.46) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7024788 0.83 GABRP (0.46) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7027131 0.82 GABRB3 (0.37) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL5206690 0.80 GABRB3 (0.39) GABRB3GABRA2GABRB2GABRPGABRD
SCHEMBL7243159 0.79 GABRB3 (0.43) GABRB3GABRA2GABRB2GABRPGABRD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030144251-A1 Pesticidal 1-arylpyrazoles RHONE-POULENC INC. 2003-07-31 US claimed
EP-0948485-B1 PESTICIDAL 1-ARYLPYRAZOLES AVENTIS CROPSCIENCE SA (FR) 2002-09-25 EP claimed
US-20020045758-A1 Pesticidal 1-arylpyrazoles RHONE-POULENC INC. 2002-04-18 US claimed
US-9609871-B2 Combination product for controlling parasites on animals BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-04-04 US disclosed
US-9609871-B2 Combination product for controlling parasites on animals BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-04-04 US disclosed
EP-2104426-B1 AGENTS FOR CONTROLLING PARASITES ON ANIMALS BAYER IP GMBH (DE) 2016-03-30 EP disclosed
US-20160007611-A1 Combination product for controlling parasites on animals ELANCO ANIMAL HEALTH GMBH (DE) 2016-01-14 US disclosed
US-20160007611-A1 Combination product for controlling parasites on animals ELANCO ANIMAL HEALTH GMBH (DE) 2016-01-14 US disclosed
US-9137995-B2 Combination product for controlling parasites on animals BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-09-22 US disclosed
US-9137995-B2 Combination product for controlling parasites on animals BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-09-22 US disclosed
US-20130045996-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2013-02-21 US disclosed
US-20100016398-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2010-01-21 US disclosed
US-20100016398-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2010-01-21 US disclosed
US-20090312387-A1 COMPOSITION FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2009-12-17 US disclosed
US-20090312387-A1 COMPOSITION FOR CONTROLLING PARASITES ON ANIMALS BAYER ANIMAL HEALTH GMBH (DE) 2009-12-17 US disclosed
US-20030144251-A1 Pesticidal 1-arylpyrazoles RHONE-POULENC INC. 2003-07-31 US disclosed
US-6500850-B2 1-ARYLPYRAZOLE OXIME DERIVATIVES; SAFE SYSTEMIC INSECTICIDES FOR CONTROL OF ARTHROPOD, NEMATODE, HELMINTH OR PROTOZOAN PESTS RHONE-POULENC INC. 2002-12-31 US disclosed
EP-0948485-B1 PESTICIDAL 1-ARYLPYRAZOLES AVENTIS CROPSCIENCE SA (FR) 2002-09-25 EP disclosed
US-20020045758-A1 Pesticidal 1-arylpyrazoles RHONE-POULENC INC. 2002-04-18 US disclosed
US-6350771-B1 Pesticidal 1-arylpyrazoles RHONE-POULENC, INC. 2002-02-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160007611-A1 Combination product for controlling parasites on animals CYCS, CYP3A43, CDIPT GABRB3 215/4885GABRA2 270/4885GABRB2 337/4885
US-20100016398-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS CYCS, CYP3A43, CDIPT GABRB3 215/4885GABRA2 270/4885GABRB2 337/4885
US-20130045996-A1 COMBINATION PRODUCT FOR CONTROLLING PARASITES ON ANIMALS CYCS, CYP3A43, CDIPT GABRB3 215/4885GABRA2 270/4885GABRB2 337/4885
US-20020045758-A1 Pesticidal 1-arylpyrazoles CYP1B1, CYP2E1, CYP1A1 GABRB3 1485/4885GABRA2 2380/4885GABRB2 1699/4885
US-20030144251-A1 Pesticidal 1-arylpyrazoles CYP1B1, CYP2E1, CYP1A1 GABRB3 1485/4885GABRA2 2380/4885GABRB2 1699/4885
US-20090312387-A1 COMPOSITION FOR CONTROLLING PARASITES ON ANIMALS CYCS, PTMS, PLCB3 GABRB3 1960/4885GABRA2 2001/4885GABRB2 2374/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.