Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14701011 | 0.73 | TP53 (0.51) | TP53CREBBPALDH1A1TSHRMAOA | |
| SCHEMBL8792194 | 0.73 | ALDH1A1 (0.62) | TP53CREBBPALDH1A1TSHRMAOA | |
| SCHEMBL3557147 | 0.73 | MAPT (0.46) | ALDH1A1TSHRMAPTKDM4ENPSR1 | |
| SCHEMBL16201673 | 0.70 | TP53 (0.51) | TP53CREBBPALDH1A1TSHRMAOA | |
| SCHEMBL17895740 | 0.68 | KDM4E (0.61) | TP53CREBBPALDH1A1TSHRMAOA | |
| SCHEMBL30223561 | 0.68 | KDM4E (0.66) | TP53CREBBPALDH1A1TSHRMAOA | |
| SCHEMBL22118133 | 0.68 | KDM4E (0.66) | TP53CREBBPALDH1A1TSHRMAOA | |
| SCHEMBL5322539 | 0.67 | TP53 (1.00) | TP53CREBBPALDH1A1TSHRMAPT | |
| SCHEMBL30395130 | 0.67 | TP53 (1.00) | TP53CREBBPALDH1A1TSHRMAPT | |
| SCHEMBL11876810 | 0.66 | HSD17B10 (0.38) | TP53ALDH1A1MAPTALOX15NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030139609-A1 | Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139609-A1 | Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles | DUT, CYC1, DHRS9 | TP53 823/4885CREBBP 3904/4885ALDH1A1 1476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.