Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | DHPS | P49366 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27502602 | 0.83 | KDM4E (0.53) | RAB9AALDH1A1KDM4EHTR3EHTR3B | |
| SCHEMBL10367391 | 0.81 | MAPT (0.52) | RAB9AHPGDALDH1A1NPC1KDM4E | |
| SCHEMBL27605120 | 0.80 | HSD17B1 (0.52) | HPGDALDH1A1HTR3EHTR3BCHRNA7 | |
| SCHEMBL938500 | 0.80 | KMO (0.52) | RAB9AHPGDALDH1A1NPC1KDM4E | |
| SCHEMBL2454052 | 0.80 | TSHR (0.53) | RAB9AHPGDALDH1A1KDM4EHTR3E | |
| SCHEMBL10367856 | 0.77 | ATM (0.55) | RAB9AHPGDALDH1A1NPC1HTR3E | |
| SCHEMBL6666581 | 0.77 | IKBKB (0.53) | HPGDALDH1A1HTR3EHTR3BCHRNA7 | |
| SCHEMBL11394556 | 0.76 | CA2 (0.50) | HPGDALDH1A1HTR3EHTR3BCHRNA7 | |
| SCHEMBL723332 | 0.75 | HDAC8 (0.70) | MAPTBAZ2BHDAC8HDAC6 | |
| SCHEMBL28875555 | 0.74 | RAB9A (0.55) | RAB9ANPC1MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027481-A9 | COMPOUNDS FOR TREATMENT OF CANCER | GTX, INC. (US) | 2013-10-10 | — | — | WO | disclosed |
| EP-2608671-A1 | COMPOUNDS FOR TREATMENT OF CANCER | Gtx, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027481-A1 | COMPOUNDS FOR TREATMENT OF CANCER | GTX, INC. (US) | 2012-03-01 | — | — | WO | disclosed |