Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.65 |
| ▸ | MEN1 | O00255 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.65 |
| ▸ | RAB9A | P51151 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.65 |
| ▸ | RELA | Q04206 | 1/20 | 0.65 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.56 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817281 | 0.82 | MEN1 (0.67) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL27408754 | 0.81 | KMT2A (0.60) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL1514839 | 0.79 | MEN1 (1.00) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL3961520 | 0.78 | GRIK1 (1.00) | GRIK1CXCR2 | |
| SCHEMBL8746726 | 0.77 | MEN1 (1.00) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL15798296 | 0.77 | MEN1 (0.72) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL5188558 | 0.77 | RAB9A (0.78) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL7254811 | 0.76 | RAB9A (0.71) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL6260101 | 0.76 | MEN1 (0.68) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL22103813 | 0.76 | GRIK1 (0.63) | NPC1MEN1KMT2ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030225125-A1 | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225125-A1 | IL-8 receptor antagonists | CXCL8, CCR8, ACKR3 | NPC1 2505/4885MEN1 4797/4885KMT2A 4312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.