Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891105 | 0.78 | KDM4E (0.44) | KMT2AALDH1A1MEN1SMN1; SMN2USP2 | |
| SCHEMBL257495 | 0.68 | FNTA (0.45) | KMT2AALDH1A1MEN1SMN1; SMN2KDM4E | |
| SCHEMBL12397750 | 0.68 | HSD17B10 (0.46) | KMT2AALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL31419458 | 0.64 | ALDH1A1 (0.40) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL9897985 | 0.64 | POLB (0.42) | KMT2AALDH1A1MEN1SMN1; SMN2USP2 | |
| SCHEMBL21295090 | 0.63 | ADORA2B (0.36) | PTGER4 | |
| SCHEMBL17434335 | 0.63 | POLB (0.40) | ALDH1A1KDM4EMAPTPOLBL3MBTL1 | |
| SCHEMBL4957913 | 0.63 | GPR35 (0.50) | KMT2AALDH1A1MEN1KDM4EGPR35 | |
| SCHEMBL1783441 | 0.62 | MEN1 (0.33) | KMT2AALDH1A1MEN1SMN1; SMN2USP2 | |
| SCHEMBL27210056 | 0.62 | CYP1A2 (0.46) | KMT2AALDH1A1MEN1SMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003035614-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-05-01 | — | — | WO | claimed |
| WO-2003035614-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-05-01 | — | — | WO | disclosed |