Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | XDH | P47989 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | GCGR | P47871 | 1/20 | 0.51 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23437869 | 0.89 | MAPK13 (0.60) | KDM4EHPGDSMN1; SMN2XDHALDH1A1 | |
| SCHEMBL23437871 | 0.85 | MAPT (0.63) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL23437865 | 0.85 | MAPK13 (0.64) | KDM4EHPGDSMN1; SMN2XDHMAPK13 | |
| SCHEMBL5157870 | 0.81 | XDH (0.59) | KDM4EHPGDSMN1; SMN2XDHALDH1A1 | |
| SCHEMBL23437867 | 0.80 | MAPK14 (0.56) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL739928 | 0.78 | MAPK13 (0.72) | KDM4EHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL31683723 | 0.78 | XDH (0.46) | KDM4EHPGDSMN1; SMN2XDHALDH1A1 | |
| SCHEMBL1980159 | 0.78 | XDH (0.50) | KDM4EHPGDSMN1; SMN2XDHALDH1A1 | |
| Benzene SCHEMBL28852698 | 0.77 | MAPK13 (0.82) | KDM4EHPGDALDH1A1MAPK13MAPK12 | |
| SCHEMBL104130 | 0.77 | MAPK13 (0.82) | KDM4EHPGDALDH1A1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
| US-5380713-A | Serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-01-10 | — | — | US | claimed |
| US-20140045779-A1 | COMPOUNDS CONTAINING AN ALICYCLIE STRUCTURE AND ANTI-TUMOR APPLICATION | XU LIFENG (US) | 2014-02-13 | — | — | US | disclosed |
| US-8646616-B2 | Composite membrane with coating comprising polyalkylene oxide and imidazol compounds | DOW GLOBAL TECHNOLOGIES LLC (US) | 2014-02-11 | — | — | US | disclosed |
| CN-103554111-A | Aromatic heterocyclic pyridine derivatives and analogs, and preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2014-02-05 | — | — | CN | disclosed |
| CN-101671336-B | Aromatic heterocyclic pyrimidine derivative and analogue, preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2013-11-13 | — | — | CN | disclosed |
| CN-103044337-A | Synthetic method of 2-(N-alkyl)aminooimidazole derivatives | UNIV NANJING SCIENCE & TECH | 2013-04-17 | — | — | CN | disclosed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
| WO-2011149572-A1 | POLYAMIDE MEMBRANE WITH COATING COMPRISING POLYALKYLENE OXIDE AND IMIDAZOL COMPOUNDS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| US-20110284454-A1 | COMPOSITE MEMBRANE WITH COATING COMPRISING POLYALKYLENE OXIDE AND IMIDAZOL COMPOUNDS | DOW GLOBAL TECHNOLOGIES LLC | 2011-11-24 | — | — | US | disclosed |
| WO-2011035518-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | 辽宁利锋科技开发有限公司 (CN) | 2011-03-31 | — | — | WO | disclosed |
| CN-101671336-A | Aromatic heterocyclic pyrimidine derivative and analogue, preparation method and application thereof | LIAONING LIFENG SCIENCE AND TE | 2010-03-17 | — | — | CN | disclosed |
| CN-101631779-A | Aspartyl protease inhibitors containing a tricyclic ring system | SCHERING CORP | 2010-01-20 | — | — | CN | disclosed |
| US-5380713-A | Serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0526877-A2 | Peptide aldehydes as antithrombotic agents | Bristol-Myers Squibb Company (US) | 1993-02-10 | — | — | EP | disclosed |
| EP-0236628-B1 | INHIBITION OF THE 5-LIPOXYGENASE PATHWAY | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-02 | — | — | EP | disclosed |
| US-4006127-A | Cationic diazacyanine dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045779-A1 | COMPOUNDS CONTAINING AN ALICYCLIE STRUCTURE AND ANTI-TUMOR APPLICATION | ALPI, SI, SLC5A11 | KDM4E 2909/4885HPGD 1298/4885SMN1; SMN2 3123/4885 |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | KDM4E 3483/4885HPGD 1664/4885SMN1; SMN2 1771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.