Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 11/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 3/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257987 | 0.85 | DRD2 (0.44) | HTR4ACHEDRD2DRD4ADRA2C | |
| SCHEMBL7259562 | 0.83 | HTR4 (0.45) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| SCHEMBL3230370 | 0.82 | HTR4 (0.64) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| Hydrochloric Acid SCHEMBL8973729 | 0.82 | HTR4 (0.63) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| SCHEMBL7254103 | 0.81 | HTR4 (0.42) | HTR4ACHEDRD2DRD4HTR3A | |
| Hydrochloric Acid SCHEMBL7257861 | 0.80 | HTR4 (0.41) | HTR4ACHEDRD2DRD4HTR3A | |
| SCHEMBL7401197 | 0.79 | HTR4 (0.62) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| SCHEMBL6328102 | 0.79 | HTR4 (0.70) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| SCHEMBL6333842 | 0.78 | HTR4 (0.58) | HTR4ACHECYP2D6CYP2C9MEN1 | |
| Oxalic Acid SCHEMBL7399228 | 0.77 | HTR4 (0.60) | HTR4ACHECYP2D6CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |