Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7254146 | 0.85 | HTR4 (0.48) | DRD2DRD4HTR4ACHEADRA2A | |
| SCHEMBL7254103 | 0.81 | HTR4 (0.42) | DRD2DRD4HTR4ACHE | |
| Hydrochloric Acid SCHEMBL8971647 | 0.81 | DRD2 (0.52) | DRD2DRD4HTR4ACHE | |
| Hydrochloric Acid SCHEMBL7257861 | 0.81 | HTR4 (0.41) | DRD2DRD4HTR4ACHE | |
| SCHEMBL6328978 | 0.78 | HTR4 (0.54) | HTR4ACHE | |
| SCHEMBL7257990 | 0.76 | KCNH2 (0.41) | DRD2KCNH2HTR4ACHE | |
| SCHEMBL7259161 | 0.72 | KCNH2 (0.34) | DRD2KCNH2 | |
| Hydrochloric Acid SCHEMBL8971855 | 0.72 | DRD2 (0.50) | DRD2DRD4HTR4ACHE | |
| SCHEMBL8970802 | 0.70 | HTR4 (0.61) | DRD2DRD4HTR4ACHE | |
| Hydrochloric Acid SCHEMBL8971667 | 0.69 | HTR4 (0.60) | DRD2DRD4HTR4ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | claimed |
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |