Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 5/20 | 0.35 |
| ▸ | JAK3 | P52333 | 5/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7257861 | 0.99 | HTR4 (0.41) | HTR4DRD2DRD4ACHEHTR3A | |
| SCHEMBL7257987 | 0.81 | DRD2 (0.44) | HTR4DRD2DRD4ACHE | |
| SCHEMBL7254146 | 0.81 | HTR4 (0.48) | HTR4DRD2DRD4ACHEHTR3A | |
| SCHEMBL7257694 | 0.81 | DRD2 (0.37) | HTR4DRD2DRD4CDK2 | |
| SCHEMBL7358352 | 0.80 | HTR4 (0.59) | HTR4DRD2DRD4ACHEHTR3A | |
| SCHEMBL6328956 | 0.76 | HTR4 (0.66) | HTR4ACHE | |
| SCHEMBL6329778 | 0.75 | HTR4 (0.67) | HTR4DRD2HTR3ACHRM1 | |
| Hydrochloric Acid SCHEMBL6329100 | 0.75 | HTR4 (0.65) | HTR4ACHE | |
| SCHEMBL7254109 | 0.70 | SLC6A2 (0.47) | HTR4DRD2ACHE | |
| Hydrochloric Acid SCHEMBL7257864 | 0.70 | SLC6A2 (0.49) | HTR4DRD2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |