Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 6/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257990 | 0.88 | KCNH2 (0.41) | KCNH2DRD2HTR4ACHE | |
| SCHEMBL7257840 | 0.87 | DRD2 (0.35) | KCNH2DRD2HTR4ACHEMEN1 | |
| SCHEMBL7254150 | 0.83 | HTR4 (0.45) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| SCHEMBL7254109 | 0.80 | SLC6A2 (0.47) | DRD2HTR4ACHE | |
| Hydrochloric Acid SCHEMBL7257864 | 0.79 | SLC6A2 (0.49) | DRD2HTR4ACHE | |
| SCHEMBL6329086 | 0.79 | HTR4 (0.52) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| SCHEMBL7259161 | 0.71 | KCNH2 (0.34) | KCNH2DRD2TLR9TLR8TLR7 | |
| SCHEMBL6328978 | 0.67 | HTR4 (0.54) | HTR4ACHEMEN1ALDH1A1CYP2D6 | |
| SCHEMBL7259567 | 0.67 | HTR4 (0.42) | KCNH2HTR4ACHEMEN1ALDH1A1 | |
| SCHEMBL7259062 | 0.67 | HTR4 (0.40) | DRD2HTR4ACHEMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003057688-A2 | OXO OR OXY-PYRIDINE COMPOUNDS AS 5-HT4 RECEPTOR MODULATORS | PFIZER JAPAN INC. (JP) | 2003-07-17 | — | — | WO | disclosed |