Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 9/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.33 |
| ▸ | TUBB | P07437 | 3/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.33 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421785 | 0.81 | TUBB4A (0.41) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL724765 | 0.79 | CYP3A4 (0.75) | CYP3A4KDM1AMAOAMAOBNR3C1 | |
| SCHEMBL3422415 | 0.66 | CYP3A4 (0.79) | CYP3A4KDM1AMAOAMAOBNR3C1 | |
| SCHEMBL3420564 | 0.66 | CYP3A4 (0.79) | CYP3A4KDM1AMAOAMAOBNR3C1 | |
| SCHEMBL1530322 | 0.66 | CYP3A4 (0.58) | CYP3A4KDM1AMAOAMAOBHRH3 | |
| SCHEMBL2112449 | 0.66 | CYP3A4 (0.63) | CYP3A4KDM1AMAOAMAOBCYP17A1 | |
| SCHEMBL12991758 | 0.64 | HSD17B10 (0.43) | MAPT | |
| SCHEMBL4608502 | 0.61 | KDM1A (0.50) | KDM1AMAOAMAOBHRH3LMNA | |
| SCHEMBL725851 | 0.61 | ERN1 (0.44) | LMNA | |
| SCHEMBL478849 | 0.60 | CA1 (0.61) | LMNAMAPTPGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158803-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2012-04-17 | — | — | US | disclosed |
| EP-2421831-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122082-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |
| US-20100272677-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | LEE EUN KYUNG | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100272677-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | POLR2A, EIF2AK2, RRM2B | CYP3A4 417/4885KDM1A 1567/4885MAOA 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.