SCHEMBL7256133

SCHEMBL7256133

COc1ccc(Nc2ccc(O)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.77
GAA P10253 4/20 0.77
RAB9A P51151 4/20 0.77
NPC1 O15118 3/20 0.77
MAPK1 P28482 2/20 0.77
KDM4E B2RXH2 2/20 0.77
THRB P10828 1/20 0.77
RECQL P46063 1/20 0.77
NPSR1 Q6W5P4 1/20 0.77
TDP1 Q9NUW8 1/20 0.77
L3MBTL1 Q9Y468 1/20 0.77
LTA4H P09960 1/20 0.64
ESR2 Q92731 1/20 0.64
NR4A1 P22736 1/20 0.63
APP P05067 2/20 0.57
VCP P55072 1/20 0.55
ALDH1A1 P00352 3/20 0.55
HTT P42858 1/20 0.55
TUBB4A P04350 1/20 0.54
TUBB P07437 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1459772 0.88 MAPT (1.00) MAPTGAARAB9ANPC1MAPK1
SCHEMBL39057 0.88 MAPT (1.00) MAPTGAARAB9ANPC1MAPK1
1,4-Dimethoxybenzene SCHEMBL8351066 0.85 ESR2 (0.84) GAARAB9ANPC1MAPK1KDM4E
Mequinol SCHEMBL1535640 0.85 ESR2 (0.84) GAARAB9ANPC1MAPK1KDM4E
Mequinol SCHEMBL166535 0.85 ESR2 (0.84) GAARAB9ANPC1MAPK1KDM4E
Mequinol SCHEMBL21009 0.85
SCHEMBL9702971 0.85 RAB9A (0.61) MAPTGAARAB9ANPC1MAPK1
SCHEMBL9703849 0.85 MAPT (0.55) MAPTGAARAB9ANPC1MAPK1
SCHEMBL24690514 0.84 MAPT (0.64) MAPTGAARAB9ANPC1MAPK1
SCHEMBL8205697 0.83 MAPT (0.53) MAPTGAARAB9ANPC1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866631-B2 Oxygenated aminophenol compounds and methods for preventing monomer polymerization ECOLAB USA INC. (US) 2024-01-09 US claimed
CN-106883132-B One kind replaces the copper that hydrazides is ligand to be catalyzed C-N coupling method with N, N- bis- 中山大学 2019-03-22 CN disclosed
CN-106883132-A With N, the substitution hydrazides of N bis- is the copper catalysis C N coupling methods of part to one kind 中山大学 2017-06-23 CN disclosed
CN-105149000-A Supported cyclometalated iridium catalyst, preparation method thereof and application of supported cyclometalated iridium catalyst in dehydrogenation reaction of dihydroindolines compounds UNIV SHAANXI NORMAL 2015-12-16 CN disclosed
US-20120034565-A1 Lithographic printing plate precursor AGFA GRAPHICS NV (BE) 2012-02-09 US disclosed
US-20120034565-A1 Lithographic printing plate precursor AGFA GRAPHICS NV (BE) 2012-02-09 US disclosed
WO-2011118845-A1 POLYESTER RESIN, AND OPTICAL MATERIALS, FILMS AND IMAGE DISPLAY DEVICES USING THE SAME FUJIFILM CORPORATION (JP) 2011-09-29 WO disclosed
WO-2010122042-A1 A LITHOGRAPHIC PRINTING PLATE PRECURSOR AGFA GRAPHICS NV (BE) 2010-10-28 WO disclosed
EP-2243628-A1 A lithographic printing plate precursor Agfa Graphics N.V. (BE) 2010-10-27 EP disclosed
WO-2003103567-A2 NITROSODIPHENYLAMINE DERIVATIVES, COMPOSITIONS COMPRISING THEM, AND THE USE THEREOF AS ANTIOXIDANTS AND SPONTANEOUS NITRIC OXIDE DONORS MERCK PATENT GMBH (DE) 2003-12-18 WO disclosed
WO-2003033467-A1 NITROSO DIPHENYLAMINE DERIVATIVES AS NITROGEN MONOXIDE GENERATING AGENTS MERCK PATENT GMBH (DE) 2003-04-24 WO disclosed
US-4719174-A USING ABSORPTIVE COMPOUND WHICH RELEASES ELECTRONS UPON EXPOSURE FUJI PHOTO FILM CO., LTD. (JP) 1988-01-12 US disclosed
US-4607006-A Silver halide photographic light-sensitive material containing non-spectral sensitizing electron donative silver halide adsorptive compound FUJI PHOTO FILM CO., LTD. (JP) 1986-08-19 US disclosed
US-4147880-A Age resisters and age resistant polymeric compositions THE GOODYEAR TIRE & RUBBER COMPANY (US) 1979-04-03 US disclosed
US-3953411-A Age resistant polymers of 4-(arylamino)aryl esters of α,β unsaturated carboxylic acids THE GOODYEAR TIRE & RUBBER COMPANY (US) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11866631-B2 Oxygenated aminophenol compounds and methods for preventing monomer polymerization HPD, DNPEP, PAH MAPT 211/4885GAA 1858/4885RAB9A 4668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.