Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.59 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.57 |
| ▸ | FEN1 | P39748 | 2/20 | 0.57 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | MB | P02144 | 1/20 | 0.55 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7108858 | 0.92 | KDM4E (0.71) | KIF11MAOAKDM4EKMT2AMTNR1A | |
| SCHEMBL28022464 | 0.85 | KIF11 (0.48) | KIF11MAOAKDM4EKMT2AMTNR1A | |
| SCHEMBL22616930 | 0.84 | MAOA (0.86) | KIF11MAOAKDM4EKMT2AMTNR1A | |
| SCHEMBL28930131 | 0.80 | KDM4E (0.67) | KIF11MAOAKDM4EKMT2AMTNR1A | |
| SCHEMBL1180474 | 0.80 | JAK2 (0.50) | KIF11MAOAKDM4EKMT2AMTNR1A | |
| SCHEMBL13394668 | 0.80 | ALDH1A1 (0.47) | KIF11MAOAKDM4EKMT2AALDH1A1 | |
| SCHEMBL23165587 | 0.79 | KMT2A (0.65) | KIF11MAOAKDM4EKMT2AMTNR1A | |
| SCHEMBL29760304 | 0.79 | KMT2A (0.65) | KIF11MAOAKDM4EKMT2AMTNR1A | |
| SCHEMBL26362351 | 0.78 | KIF11 (0.48) | KIF11MAOAKDM4EKMT2AMTNR1A | |
| SCHEMBL124178 | 0.76 | KDM4E (0.57) | KDM4EKMT2AALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030040538-A1 | Novel substituted tricyclic compounds | ASAHI-KASEI KABUSHIKI KAISHA (JP) | 2003-02-27 | — | — | US | disclosed |
| EP-1238973-A1 | NOVEL SUBSTITUTED TRICYCLIC COMPOUNDS | Asahi Kasei Kabushiki Kaisha (JP) | 2002-09-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030040538-A1 | Novel substituted tricyclic compounds | CPT1A, CBR1, NR1H3 | KIF11 4358/4885MAOA 2743/4885KDM4E 1429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.