Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7260503 | 0.83 | MAPK1 (0.44) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL7261133 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL7259113 | 0.80 | HPGD (0.47) | MEN1KMT2ADYRK1AGSK3AGSK3B | |
| SCHEMBL7256511 | 0.79 | EGFR (0.47) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL7260065 | 0.79 | NPC1 (0.48) | MEN1KMT2ADYRK1AGSK3AGSK3B | |
| SCHEMBL8834226 | 0.73 | POLB (0.43) | MEN1KMT2ACDK4CCND1DYRK1A | |
| SCHEMBL5222119 | 0.73 | KMT2A (0.44) | MEN1KMT2ACDK4CCND1HSP90AA1 | |
| SCHEMBL29930500 | 0.72 | DYRK1A (0.47) | MEN1KMT2ACDK4CCND1DYRK1A | |
| SCHEMBL28562998 | 0.72 | DYRK1B (0.61) | MEN1KMT2AHSP90AA1DYRK1AGSK3A | |
| SCHEMBL23700852 | 0.70 | KDM4E (0.44) | MEN1KMT2ACDK4CCND1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | claimed |
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |