Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 3/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7260503 | 0.84 | MAPK1 (0.44) | ALDH1A1SMN1; SMN2MAP2K4MAPK1MAPK6 | |
| SCHEMBL7259113 | 0.83 | HPGD (0.47) | ALDH1A1SMN1; SMN2MAP2K4ADORA3ADORA1 | |
| SCHEMBL7256520 | 0.80 | MEN1 (0.47) | ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL7255654 | 0.72 | IDO1 (0.40) | ALDH1A1SMN1; SMN2HTR2B | |
| SCHEMBL9193977 | 0.72 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL1592860 | 0.70 | KIT (0.49) | ALDH1A1SMN1; SMN2KITMAP2K4MAPK1 | |
| SCHEMBL14895595 | 0.70 | MAPK1 (0.56) | MAP2K4MAPK1MAPK6MAP2K7 | |
| SCHEMBL30881437 | 0.70 | MAPK1 (0.44) | ALDH1A1SMN1; SMN2KITMAP2K4MAPK1 | |
| SCHEMBL27244026 | 0.70 | MAPK1 (0.44) | ALDH1A1SMN1; SMN2KITMAP2K4MAPK1 | |
| SCHEMBL24186352 | 0.70 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAP2K4HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | claimed |
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |