Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | FER | P16591 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261133 | 0.83 | ALDH1A1 (0.44) | ALDH1A1MAP2K4ADORA3ADORA1SMN1; SMN2 | |
| SCHEMBL7260503 | 0.83 | MAPK1 (0.44) | HPGDALDH1A1KDM4EMAP2K4RAB9A | |
| SCHEMBL7255610 | 0.81 | GSK3A (0.53) | HPGDALDH1A1KDM4EMAPK10GAA | |
| SCHEMBL7256520 | 0.80 | MEN1 (0.47) | HPGDALDH1A1KDM4EGAAALPL | |
| SCHEMBL7260051 | 0.75 | GSK3A (0.46) | IDO1ADORA1NPC1RAB9ATP53 | |
| SCHEMBL7255654 | 0.74 | IDO1 (0.40) | HPGDALDH1A1IDO1ALPLMAPT | |
| SCHEMBL1513071 | 0.74 | KDM4E (0.53) | HPGDALDH1A1KDM4EMAPK10GAA | |
| SCHEMBL7256481 | 0.73 | DCLK1 (0.51) | HPGDALDH1A1KDM4EMAPK10GAA | |
| SCHEMBL7261231 | 0.73 | GSK3A (0.50) | HPGDALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL13738909 | 0.72 | GSK3B (0.44) | HPGDALDH1A1KDM4EMAPK10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | claimed |
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |