Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261133 | 0.84 | ALDH1A1 (0.44) | MAPK1ALDH1A1SMN1; SMN2MAP2K4MAPK6 | |
| SCHEMBL7259113 | 0.83 | HPGD (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2AMAP2K4 | |
| SCHEMBL7256520 | 0.83 | MEN1 (0.47) | MAPK1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7261231 | 0.77 | GSK3A (0.50) | MAPK1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19244018 | 0.75 | ADORA2A (0.34) | — | |
| SCHEMBL7256511 | 0.74 | EGFR (0.47) | MAPK1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7255654 | 0.72 | IDO1 (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL18513164 | 0.70 | ALDH1A1 (0.44) | MAPK1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16517285 | 0.70 | TDP1 (0.40) | MAPK1KDM4EMAPT | |
| SCHEMBL16516933 | 0.68 | TDP1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003080616-A1 | PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3 | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |