Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 13/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11632294 | 0.81 | SIRT1 (0.45) | SIRT1SIRT2SIRT3RECQLUSP2 | |
| SCHEMBL7263508 | 0.80 | SIRT1 (0.44) | SIRT1SIRT2ADRA2ASIRT3RECQL | |
| SCHEMBL5520518 | 0.79 | CA1 (0.55) | — | |
| SCHEMBL7263632 | 0.79 | ALDH1A1 (0.52) | ADRA2AHSD17B2RECQLHSD17B10 | |
| SCHEMBL11415732 | 0.79 | ADRA2A (0.40) | SIRT1SIRT2ADRA2AHSD17B2GID4 | |
| SCHEMBL28279922 | 0.78 | GID4 (0.41) | SIRT1ADRA2AHSD17B2GID4 | |
| SCHEMBL11636914 | 0.77 | SIRT1 (0.44) | SIRT1SIRT2SIRT3RECQL | |
| SCHEMBL31396122 | 0.77 | GID4 (0.44) | SIRT1ADRA2AHSD17B2GID4 | |
| SCHEMBL11634027 | 0.76 | SIRT1 (0.43) | SIRT1SIRT2SIRT3RECQL | |
| SCHEMBL11418325 | 0.76 | ADRA2A (0.38) | SIRT1SIRT2ADRA2AHSD17B2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614898-B1 | INDOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF | TORAY INDUSTRIES (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-6291470-B1 | DELTA-OPIOID ANTAGONIST HAVING HIGH SELECTIVITY AND ACTIVITY, THAT EXHIBITS IMMUNOSUPPRESSIVE ACTION, ANTIALLERGIC ACTION, ANTI-INFLAMMATORY ACTION AND BRAIN CELL-PROTECTING ACTION | TORAY INDUSTRIES, INC. (JP) | 2001-09-18 | — | — | US | disclosed |
| US-6087369-A | AN IMMUNOSUPPRESSIVE AGENT, ANTIALLERGIC AGENT, ANTI-INFLAMMATORY AGENT AND BRAIN CELL-PROTECTING AGENT | TORAY INDUSTRIES, LTD. (JP) | 2000-07-11 | — | — | US | disclosed |
| US-5852030-A | Indole derivatives, process for producing the same and medicinal uses of the same | TORAY INDUSTRIES, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0614898-A1 | INDOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1994-09-14 | — | — | EP | disclosed |