SCHEMBL7258447

SCHEMBL7258447

COc1ccc(Cn2cc(N)c(N)n2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
KMT2A Q03164 1/20 0.47
AADAT Q8N5Z0 1/20 0.46
ALDH1A1 P00352 2/20 0.45
KDM4E B2RXH2 1/20 0.45
MAPT P10636 1/20 0.45
ALOX15 P16050 1/20 0.45
CMA1 P23946 1/20 0.45
PTGS2 P35354 1/20 0.44
CYP2D6 P10635 2/20 0.44
ATM Q13315 1/20 0.44
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
IDO1 P14902 2/20 0.43
CYP19A1 P11511 2/20 0.43
GSK3A P49840 1/20 0.42
GSK3B P49841 1/20 0.42
SIGMAR1 Q99720 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17459011 0.86 MEN1 (0.49) MEN1NPC1RAB9AKMT2AAADAT
SCHEMBL25027880 0.84 PTGS2 (0.45) MEN1NPC1RAB9AKMT2AAADAT
SCHEMBL27186732 0.84 MEN1 (0.45) MEN1NPC1RAB9AKMT2AAADAT
SCHEMBL16784448 0.84 KMT2A (0.57) MEN1NPC1RAB9AKMT2AAADAT
SCHEMBL31052484 0.83 AADAT (0.49) MEN1NPC1RAB9AKMT2AAADAT
SCHEMBL27396230 0.82 AADAT (0.48) MEN1NPC1RAB9AKMT2AAADAT
SCHEMBL17459119 0.81 HSP90AA1 (0.43) MEN1NPC1RAB9AKMT2AAADAT
SCHEMBL21796563 0.81 RAB9A (0.49) MEN1NPC1RAB9AKMT2AAADAT
SCHEMBL21797096 0.81 CYP19A1 (0.49) MEN1NPC1RAB9AKMT2AAADAT
SCHEMBL4100807 0.80 ALDH1A1 (0.49) MEN1NPC1RAB9AKMT2AAADAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1313434-A1 OXIDATION DYE Wella Aktiengesellschaft (DE) 2003-05-28 EP claimed
WO-2002069919-A1 OXIDATION DYE WELLA AKTIENGESELLSCHAFT (DE) 2002-09-12 WO claimed