Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258709 | 0.77 | KDR (0.54) | MAPTMEN1KMT2ASTK17ANPC1 | |
| SCHEMBL14046318 | 0.76 | ALOX15 (0.64) | MAPTHPGDMEN1KMT2AL3MBTL1 | |
| SCHEMBL7253695 | 0.73 | NPC1 (0.54) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL4772394 | 0.71 | RAB9A (0.65) | MAPTHPGDRAB9AMEN1KMT2A | |
| SCHEMBL16385836 | 0.68 | SMN1; SMN2 (0.61) | MAPTHPGDRAB9AMEN1KMT2A | |
| SCHEMBL28830798 | 0.68 | MAPT (0.67) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL16621476 | 0.67 | L3MBTL1 (0.52) | MAPTHPGDMEN1KMT2AL3MBTL1 | |
| SCHEMBL17784180 | 0.67 | HPGD (0.55) | MAPTHPGDRAB9AMEN1KMT2A | |
| SCHEMBL10149114 | 0.67 | PTK2 (0.52) | MAPTHPGDRAB9AMEN1KMT2A | |
| SCHEMBL27480439 | 0.66 | CHRNB2 (0.54) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003030909-A1 | 2- AND 4-AMINOPYRIMIDINES N-SUBSTTITUDED BY A BICYCLIC RING FOR USE AS KINASE INHIBITORS IN THE TREATMENT OF CANCER | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-17 | — | — | WO | disclosed |