Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27574983 | 0.87 | CA12 (0.39) | KDM4EALDH1A1SMN1; SMN2GABRA1GABRB2 | |
| SCHEMBL27775355 | 0.81 | GABRP (0.40) | KDM4EALDH1A1SMN1; SMN2METAP2GABRA1 | |
| SCHEMBL9139692 | 0.81 | ALDH1A1 (0.39) | KDM4EALDH1A1SMN1; SMN2METAP2GABRA1 | |
| SCHEMBL10694897 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1METAP2GABRA1GABRB2 | |
| SCHEMBL1997421 | 0.81 | METAP2 (0.42) | KDM4EALDH1A1SMN1; SMN2METAP2GABRA1 | |
| SCHEMBL1542173 | 0.80 | GABRP (0.37) | KDM4EALDH1A1SMN1; SMN2METAP2GABRA1 | |
| SCHEMBL311734 | 0.79 | SMN1; SMN2 (0.43) | KDM4EALDH1A1SMN1; SMN2METAP2GABRA1 | |
| SCHEMBL18795788 | 0.79 | METAP2 (0.35) | KDM4EALDH1A1SMN1; SMN2METAP2GABRA1 | |
| SCHEMBL8895032 | 0.79 | ALDH1A1 (0.36) | KDM4EALDH1A1SMN1; SMN2METAP2GABRA1 | |
| SCHEMBL10718190 | 0.79 | NOS2 (0.43) | KDM4EALDH1A1METAP2GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003027089-A1 | BENZOFURAN, INDOLE OR BENZOTHIOPHENE 2,4-PENTADIENOIC ACID DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X (RXR) RECEPTORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |
| US-6388105-B1 | ANTIPROLIFERATIVE AGENTS; SKIN DISORDERS; ANTIINFLAMMATORY AGENTS | ALLERGAN SALES, INC. | 2002-05-14 | — | — | US | disclosed |