Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | KRAS | P01116 | 2/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.40 |
| ▸ | GAK | O14976 | 9/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 6/20 | 0.37 |
| ▸ | COQ8A | Q8NI60 | 6/20 | 0.37 |
| ▸ | NLK | Q9UBE8 | 6/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.37 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.37 |
| ▸ | TXK | P42681 | 1/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263674 | 0.74 | THRB (0.44) | FGFR2 | |
| SCHEMBL6692635 | 0.73 | BCL6 (0.41) | EGFRBCL6 | |
| SCHEMBL7263135 | 0.72 | KRAS (0.33) | KRASSOS1 | |
| SCHEMBL24942886 | 0.69 | CYP2D6 (0.47) | — | |
| SCHEMBL26239898 | 0.68 | ALDH1A1 (0.43) | — | |
| SCHEMBL8119851 | 0.65 | NFE2L2 (0.43) | — | |
| SCHEMBL10094295 | 0.65 | ABCG2 (0.50) | — | |
| SCHEMBL15248196 | 0.65 | RPS6KA3 (0.39) | — | |
| SCHEMBL11984410 | 0.62 | ALDH1A1 (0.58) | — | |
| SCHEMBL26400628 | 0.62 | KRAS (0.35) | KRASSOS1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003094845-A2 | PYRIDINE-BASED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-20 | — | — | WO | disclosed |