Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 5/20 | 0.32 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
| ▸ | PTGIR | P43119 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263674 | 0.74 | THRB (0.44) | PDGFRAP2RX3P2RX2THRBRORC | |
| SCHEMBL6690378 | 0.73 | THRB (0.36) | KDRPOLBGAAGFERP2RX3 | |
| SCHEMBL7259057 | 0.72 | EGFR (0.46) | KRASSOS1 | |
| SCHEMBL282452 | 0.71 | GAA (0.43) | POLBGAAGFERP2RX3P2RX2 | |
| SCHEMBL20780317 | 0.69 | GAA (0.47) | POLBGAAGFERALDH1A1TSHR | |
| SCHEMBL282378 | 0.66 | AR (0.45) | POLBGAAGFERALDH1A1TSHR | |
| SCHEMBL8119851 | 0.65 | NFE2L2 (0.43) | POLBGAAGFERP2RX3P2RX2 | |
| SCHEMBL6765574 | 0.65 | GAA (0.45) | KDRPOLBGAAGFERP2RX3 | |
| SCHEMBL15248196 | 0.65 | RPS6KA3 (0.39) | TSHRCA1CA2 | |
| SCHEMBL7353139 | 0.64 | THRB (0.40) | P2RX3P2RX2ALDH1A1THRBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003094845-A2 | PYRIDINE-BASED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-20 | — | — | WO | disclosed |