Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL71665 | 0.91 | ALDH1A1 (0.40) | HRH3SMN1; SMN2CTSLALDH1A1MEN1 | |
| SCHEMBL2429386 | 0.79 | SMN1; SMN2 (0.39) | HRH3SMN1; SMN2CTSLALDH1A1MEN1 | |
| SCHEMBL2435371 | 0.77 | SMN1; SMN2 (0.35) | HRH3SMN1; SMN2CTSLALDH1A1MEN1 | |
| SCHEMBL2432110 | 0.77 | SMN1; SMN2 (0.35) | HRH3SMN1; SMN2CTSLALDH1A1MEN1 | |
| SCHEMBL1171079 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL1171081 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL9935314 | 0.76 | HSD17B10 (0.36) | HRH3SMN1; SMN2CTSLKMT2AHPGD | |
| SCHEMBL2433600 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL2433598 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL2431969 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1961750-B1 | VLA-4 INHIBITORY DRUG | DAIICHI SANKYO CO LTD (JP) | 2013-09-18 | — | — | EP | disclosed |
| US-20130065882-A1 | VLA-4 inhibitory drug | MACHINAGA NOBUO (JP) | 2013-03-14 | — | — | US | disclosed |
| US-20120157437-A1 | VLA-4 INHIBITORY DRUG | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-06-21 | — | — | US | disclosed |
| US-8129366-B2 | VLA-4 inhibitory drug | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-20090233901-A1 | VLA-4 INHIBITORY DRUG | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-09-17 | — | — | US | disclosed |
| EP-1961750-A1 | VLA-4 INHIBITORY DRUG | Daiichi Sankyo Company, Limited (JP) | 2008-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157437-A1 | VLA-4 INHIBITORY DRUG | VCAM1, ITGB4, ITGA4 | HRH3 314/4885SMN1; SMN2 4739/4885CTSL 1719/4885 |
| US-20130065882-A1 | VLA-4 inhibitory drug | VCAM1, ITGB4, ITGA4 | HRH3 372/4885SMN1; SMN2 4702/4885CTSL 1683/4885 |
| US-20090233901-A1 | VLA-4 INHIBITORY DRUG | VCAM1, ITGB4, ITGA4 | HRH3 247/4885SMN1; SMN2 4787/4885CTSL 1909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.