Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261286 | 0.89 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDDYRK1AMEN1 | |
| SCHEMBL2430387 | 0.83 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDDYRK1AMEN1 | |
| SCHEMBL7257608 | 0.81 | RET (0.44) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL436409 | 0.78 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDDYRK1AMEN1 | |
| SCHEMBL7509122 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7261298 | 0.77 | POLB (0.53) | KDM4EALDH1A1HPGDDYRK1AMEN1 | |
| SCHEMBL2429913 | 0.76 | NR3C1 (0.48) | KDM4EALDH1A1HPGDDYRK1AMEN1 | |
| SCHEMBL2432181 | 0.76 | HPGD (0.43) | KDM4EALDH1A1HPGDDYRK1AATM | |
| Hydrochloric Acid SCHEMBL30353212 | 0.75 | ALDH1A1 (0.97) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL28187483 | 0.75 | ALDH1A1 (0.97) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645983-B1 | Heterocyclic imines such as 3-(4-methoxyphenyl)-1,4-dihydro-4 -quinolinone, used as anticarcinogenic agents having cytolysis efficiency; side effect reduction | LABORATOIRE L. LAFON (FR) | 2003-11-11 | — | — | US | disclosed |
| EP-1202971-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| WO-2002022074-A2 | USE OF 2- AND 4- QUINOLONES FOR INHIBITING INTIMAL NEO-PROLIFERATION | LABORATOIRE L. LAFON (FR) | 2002-03-21 | — | — | WO | disclosed |
| WO-2001012607-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES FOR TREATING CANCERS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |