Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 3/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PNP | P00491 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472533 | 0.86 | AKR1B1 (0.40) | PDE3BPDE3ADAONR4A2NPC1 | |
| SCHEMBL14604111 | 0.82 | GAA (0.45) | PDE3BPDE3ADAOSMN1; SMN2RAB9A | |
| SCHEMBL6471052 | 0.79 | RNASEH1 (0.47) | KDM4AKDM5BPNP | |
| SCHEMBL16881268 | 0.78 | NAPRT (0.34) | PDE3BPDE3ADAOKDM4AKDM4C | |
| SCHEMBL16486420 | 0.76 | TSHR (0.43) | DAOKDM4CRAB9AKDM4EKMT2A | |
| SCHEMBL16880471 | 0.76 | NAPRT (0.39) | DAOKDM4CKDM4E | |
| SCHEMBL4649823 | 0.75 | KDM4E (0.45) | DAOKDM4AKDM4CSMN1; SMN2NPC1 | |
| SCHEMBL7432519 | 0.74 | DAO (0.42) | PDE3BPDE3ADAOSMN1; SMN2RAB9A | |
| SCHEMBL4969020 | 0.73 | TSHR (0.42) | LMNASMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL6209517 | 0.73 | NOTUM (0.53) | DAONPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360489-A1 | LOW AFFINITY SCREENING METHOD | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002063299-A1 | LOW AFFINITY SCREENING METHOD | GRAFFINITY PHARMACEUTICALS AG (DE) | 2002-08-15 | — | — | WO | disclosed |