Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14604111 | 0.78 | GAA (0.45) | TSHRSMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL7262256 | 0.73 | PDE3B (0.47) | ALDH1A1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL6472533 | 0.73 | AKR1B1 (0.40) | ALDH1A1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL16486420 | 0.72 | TSHR (0.43) | TSHRCYP2C9KMT2ACYP1A2CYP2C19 | |
| SCHEMBL6209517 | 0.72 | NOTUM (0.53) | ALDH1A1TDP1KMT2AMEN1POLB | |
| SCHEMBL4649050 | 0.71 | PNP (0.42) | ALDH1A1LMNAKMT2AMEN1L3MBTL1 | |
| SCHEMBL4649823 | 0.71 | KDM4E (0.45) | TSHRALDH1A1SMN1; SMN2CYP2C9CYP1A2 | |
| SCHEMBL7108447 | 0.71 | TSHR (0.43) | TSHRALDH1A1TDP1KMT2AMEN1 | |
| SCHEMBL29089235 | 0.71 | TSHR (0.39) | TSHRALDH1A1HPGDTDP1KMT2A | |
| SCHEMBL6471052 | 0.69 | RNASEH1 (0.47) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954693-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062007-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |