Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PNP | P00491 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PTPRA | P18433 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14604111 | 0.80 | GAA (0.45) | KDM4EDAOTSHRSMN1; SMN2RAB9A | |
| SCHEMBL14273024 | 0.76 | RAB9A (0.46) | KDM4EMAPTKDM4CSMN1; SMN2CYP1A2 | |
| SCHEMBL4649050 | 0.76 | PNP (0.42) | PNPDAOALDH1A1L3MBTL1 | |
| SCHEMBL7262256 | 0.75 | PDE3B (0.47) | KDM4EPNPMAPTDAOKDM4C | |
| SCHEMBL31691416 | 0.72 | KDM4E (0.45) | KDM4EMAPTKDM4CSMN1; SMN2CYP1A2 | |
| SCHEMBL6472533 | 0.72 | AKR1B1 (0.40) | DAONPC1RAB9AALDH1A1L3MBTL1 | |
| SCHEMBL8829787 | 0.72 | PNP (0.49) | KDM4EPNPMAPTDAOTSHR | |
| SCHEMBL6612453 | 0.71 | HRH4 (0.42) | KDM4ETSHRKDM4CSMN1; SMN2CYP1A2 | |
| SCHEMBL16486420 | 0.71 | TSHR (0.43) | KDM4EDAOTSHRKDM4CCYP1A2 | |
| SCHEMBL4969020 | 0.71 | TSHR (0.42) | KDM4EMAPTTSHRSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960367-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007067836-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-14 | — | — | WO | disclosed |