Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212288 | 0.82 | AKT1 (0.53) | TGFBR1MAPK14LMNAHTTATM | |
| SCHEMBL10981794 | 0.80 | AKT1 (0.52) | TGFBR1MAPK14LMNAHTTATM | |
| SCHEMBL9824714 | 0.77 | NISCH (0.51) | TGFBR1MAPK14LMNACSNK1A1CYP1A2 | |
| SCHEMBL7283286 | 0.75 | TGFBR1 (0.47) | TGFBR1MAPK14LMNATGFBR2ABL2 | |
| SCHEMBL3667468 | 0.74 | PARP1 (0.45) | TGFBR1CYP2A6LMNANPY5RSMN1; SMN2 | |
| SCHEMBL2511846 | 0.74 | LMNA (0.47) | LMNASMN1; SMN2HTTATMCYP1A2 | |
| SCHEMBL3753128 | 0.74 | PRKCI (0.47) | TGFBR1MAPK14LMNATGFBR2ABL2 | |
| SCHEMBL4510667 | 0.74 | LMNA (0.56) | TGFBR1MAPK14LMNATGFBR2ABL2 | |
| SCHEMBL23294714 | 0.72 | TGFBR1 (0.54) | TGFBR1MAPK14LMNATGFBR2ABL2 | |
| SCHEMBL29852117 | 0.72 | TGFBR1 (0.54) | TGFBR1MAPK14LMNATGFBR2ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178875-B1 | PYRIDYLPHENYLPYRIDAZINONE INOTROPIC AGENTS | ELI LILLY AND COMPANY (US) | 1989-04-12 | — | — | EP | disclosed |
| EP-0178875-A1 | Pyridylphenylpyridazinone inotropic agents | ELI LILLY AND COMPANY (US) | 1986-04-23 | — | — | EP | disclosed |
| EP-0178875-A1 | Pyridylphenylpyridazinone inotropic agents | ELI LILLY AND COMPANY (US) | 1986-04-23 | — | — | EP | disclosed |