Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7264282 | 0.75 | TGFBR1 (0.59) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL3753128 | 0.73 | PRKCI (0.47) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL10413171 | 0.71 | TGFBR1 (0.77) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL16556061 | 0.71 | TGFBR1 (0.53) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL15314119 | 0.69 | AKT1 (0.56) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL4510667 | 0.69 | LMNA (0.56) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL12313143 | 0.69 | TGFBR1 (0.51) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL398499 | 0.69 | KDM4E (0.50) | TGFBR1KDM4ELMNAPOLBCYP1A2 | |
| SCHEMBL23294714 | 0.68 | TGFBR1 (0.54) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 | |
| SCHEMBL29852117 | 0.68 | TGFBR1 (0.54) | TGFBR1MAPK14TGFBR2ABL2CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4656170-A | CARDIOTONIC, HYPOTENSIVE, ANTITHROMBOTIC | WARNER-LAMBERT COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| US-4599332-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1986-07-08 | — | — | US | disclosed |
| EP-0081906-B1 | PHARMACEUTICALLY-ACTIVE PYRIDYLVINYLPYRIDAZINONES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-07-24 | — | — | EP | disclosed |
| EP-0081906-B1 | PHARMACEUTICALLY-ACTIVE PYRIDYLVINYLPYRIDAZINONES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-07-24 | — | — | EP | disclosed |
| EP-0145450-A2 | 6- [2-[4-(1H-imidazol-1-yl)phenyl]-alkylene and alkylenyl]-3(2H)-pyridazinones, the 4,5-dihydro- pyridazinone derivatives thereof, and a process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1985-06-19 | — | — | EP | disclosed |
| US-4508721-A | Pyridazin-3-one derivatives | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1985-04-02 | — | — | US | disclosed |
| EP-0081906-A1 | Pharmaceutically-active pyridylvinylpyridazinones | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-06-22 | — | — | EP | disclosed |
| EP-0081906-A1 | Pharmaceutically-active pyridylvinylpyridazinones | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-06-22 | — | — | EP | disclosed |