Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | SCN1A | P35498 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273125 | 0.91 | LMNA (0.47) | MAPTKMT2AADORA3LMNACYP1A2 | |
| SCHEMBL7272935 | 0.87 | ADORA3 (0.46) | MAPTKMT2AADORA3LMNACYP1A2 | |
| SCHEMBL10997036 | 0.86 | MAPT (0.68) | MAPTKMT2AADORA3LMNACYP1A2 | |
| SCHEMBL7265676 | 0.85 | ALDH1A1 (0.38) | MAPTKMT2AADORA3LMNACYP1A2 | |
| SCHEMBL6427770 | 0.83 | ADORA3 (0.67) | MAPTKMT2AADORA3LMNACYP1A2 | |
| SCHEMBL10369519 | 0.83 | ADORA3 (0.58) | MAPTKMT2AADORA3LMNACYP1A2 | |
| SCHEMBL7264444 | 0.83 | KMT2A (0.42) | MAPTKMT2AADORA3CACNA1CTP53 | |
| SCHEMBL7263816 | 0.82 | CYP2C9 (0.45) | MAPTKMT2AADORA3LMNACYP1A2 | |
| SCHEMBL7264423 | 0.82 | MEN1 (0.48) | MAPTKMT2AADORA3LMNACYP1A2 | |
| SCHEMBL10998379 | 0.80 | CACNA1C (0.54) | MAPTKMT2AADORA3LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116708-A1 | Substituted 1,4-dihydropyridines, method for their preparation and their use as pharmaceuticals | CASSELLA Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |